Human hypoxia inducible factor-1 alpha recombinant adenovirus carrier and uses thereof

• Main Authors: LIU CHENG, CHEN WEI, XIE YIJUN, WU PINGSHENG, WANG YUEGANG, GUO SHOUGUI, TONG KAI, HU YINGFANG, FU RUIBIN, LAI YANXIAN
• Format: Patent
• Language: Chinese; English
• Published: 19.11.2008
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention relates to a mutant hypoxia inducible factor 1alpha, coded nucleic acid of the mutant hypoxia inducible factor 1alpha, a carrier containing wild coded nucleic acid of the mutant hypoxia inducible factor 1alpha, in particular to a recombinant adenovirus carrier and a drug composition containing the mutant hypoxia inducible factor 1 alpha, the coded nucleic acid and the carriers. The mutant protein, the nucleic acid, the carriers and the drug composition can be used to treat ischemic diseases, such as coronary heart disease, peripheral arterial ischemic vascular diseases, intermittent claudication and so on.