Method for synthesizing oxazoline-2-ketone

A method for synthesizing or substituting oxazoline-2-ketone comprises the steps of performing cyclocarbonylation with beta-amino alcohols as reactant and CO as carbonylation reagent and in the presence of selenium catalyst to obtain oxazoline-2-ketone, wherein the molar ratio of selenium catalyst a...

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Bibliographic Details
Main Authors LI PENG, WANG SHUDONG, YU JUNXUE, YUAN XIAOHUA, LU SHIWEI
Format Patent
LanguageChinese
English
Published 11.05.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A method for synthesizing or substituting oxazoline-2-ketone comprises the steps of performing cyclocarbonylation with beta-amino alcohols as reactant and CO as carbonylation reagent and in the presence of selenium catalyst to obtain oxazoline-2-ketone, wherein the molar ratio of selenium catalyst and the reactant is 1-20% (mol), the reaction time is 2-20 hours, the reaction temperature is 10-100DEG C, and the CO pressure is 1atm. By using the inventive method, the product has selectivity over 99% and has no racemization to chiral substrates, both the selenium catalyst and the solvent can berecycled, and the catalytic activity is substantially unchanged, so as to solve the difficulty of difficult separation of a catalyst and a product in a homogeneous catalysis.
Bibliography:Application Number: CN2007198699