Sustained release of antifectives

Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio of about 1:1 to about 4:1, and a mean average diameter of less than about 1 µm Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion proces...

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Bibliographic Details
Main Authors MALININ VLADIMIR, MILLER BRIAN S, LI XINGONG, BONI LAWRENCE
Format Patent
LanguageChinese
English
Published 07.08.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio of about 1:1 to about 4:1, and a mean average diameter of less than about 1 µm Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.
Bibliography:Application Number: CN200680034397