Macromolecule material drug carrier system for targeted therapy and preparation and application thereof

• Main Authors: QI XUELIAN, WANG CHENGJI, LIU PEIFENG, ZHANG JUN, DUAN YOURONG, YAN ZHUBING, LIANG DANDAN
• Format: Patent
• Language: Chinese; English
• Published: 17.09.2008
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention relates to a macromolecular material drug carrier system with multiple target effect and the preparation method and the purpose, belonging to the technical field of target administration. The macromolecular material drug carrier system adopts pluronic as drug carrier to prepare pluronic copolymer hydrogel or micelle, or short peptide modified pluronic copolymer hydrogel or micelle. The copolymer material is liquid at ambient temperature, and can be self-assembled into nanometer micelle to wrap the drug; the copolymer material is solid in body temperature environment, and the administration can be local or across the body. The invention also discloses the function of the hydrogel or micelle carrier for controlling the drug release under the action of ultrasonic. The drug carrier material can be used for organic, water soluble or oil soluble drug. The macromolecular material drug carrier system has the advantages of simple preparation method and applicability to mass production, in particular to t