Preparation method for 5-hydroxymethylthiazole

The invention relates to a method for preparing 5-hydroxymethyl thiazole, which belongs to the drug production technical field. The invention includes the following steps that: the esterification between 2-chloro-5-chloromethyl thiazole and sodium acetate trihydrate is performed in ethanol; after pu...

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Bibliographic Details
Main Authors ZHANG SHIXI, SUN HANZHOU, LI CAIFA, XIE WEIYUE, WANG XINHUA, CHEN JIAOSHOU, JIANG YOUQING, LEI LIANGPING
Format Patent
LanguageChinese
English
Published 10.09.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a method for preparing 5-hydroxymethyl thiazole, which belongs to the drug production technical field. The invention includes the following steps that: the esterification between 2-chloro-5-chloromethyl thiazole and sodium acetate trihydrate is performed in ethanol; after purification, the product obtained from esterification is deoxidized in the ethanol by zinc powder; and then the product obtained from deoxidization is hydrolyzed by sodium hydroxide to obtain the target product, which is condensed, filtered and distilled to yield the final product. The method for preparing 5-hydroxymethyl thiazole provided by the invention is characterized in original technology, advanced technique, simplified technology, and safe production. The final product has the advantages of steady performance, high content and low impurities, etc.
Bibliography:Application Number: CN2008131114