9-N-substituted berberine derivatives as well as preparation method and use as anti-cancer drugs

The invention disclose 9-N-substituted berberine derivates, a method for making same and applications as anticancer drugs, wherein the chemical formula is shown as the formula I, n is selected from 1-6; R is selected form H, amino, C1-C6 amido, hydroxyl, alkoxyl, alkoxyl, benzene ring or substituted...

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Bibliographic Details
Main Authors HOU JINQIANG, GU LIANQUAN, OU TIANMIAO, HUANG ZHISHU, MA YAN
Format Patent
LanguageChinese
English
Published 23.06.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention disclose 9-N-substituted berberine derivates, a method for making same and applications as anticancer drugs, wherein the chemical formula is shown as the formula I, n is selected from 1-6; R is selected form H, amino, C1-C6 amido, hydroxyl, alkoxyl, alkoxyl, benzene ring or substituted benzene ring; m is selected from 0-1; anion X<-> is selected from halogen anion, sulfate anion, hydrogen sulfate anion, etc. the 9-N-substituted berberine derivates have strong interaction with protooncogene c-mycDNA rich in guanine, have good inhibitory activity to telomere and telomerase in cancer cells, and have strong inhibition to the expression of protooncogene c-myc. Proved by experiment, the 9-N-substituted berberine derivates of the invention have substantial inhibition to various cancer cell line, have small toxicity to normal cells, and may be used for preparing anticancer drugs. The 9-N-substituted berberine derivates of the invention has a simple preparation method, a substantial potency, and have gre
Bibliography:Application Number: CN2008127095