Hepatitis c virus hypervariable region 1 antigen and its use in preparation of hepatitis c virus detection reagent

• Main Authors: LING SHIGAN, YAN JINQI, SONG XIAOGUO, LI ZHAO, ZHANG HEQIU, XIU BINGSHUI, WANG GUOHUA
• Format: Patent
• Language: Chinese; English
• Published: 25.05.2011
• Subjects: CHEMISTRY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; TESTING

The invention discloses a hypervariable region 1 antigen in hepatitis C virus (HCV), and also discloses the purpose of the antigen in the preparation of hepatitis C virus detection reagent. The invention adopts the biological information technology to analyze the hypervariable region 1 sequence of the hepatitis C virus, seventeen HVR1 multi-target antigens with the variant specificity are screened out, a indirect enzyme-linked immunosorbent assay is adopted to detect the serum of the patient and the antigen reactivity condition of the seventeen HVR1 antigens, according to the alloplasm degree of the HVR1 antibody, the variance state of the virus is judged, the purpose of the HCV variance detection is attained through the heterogeneity detection of the antibody of the hypervariable region 1 antigen (HVR1) of the hepatitis C virus, and the problems of finial result and prognosis of the HCV disease, and prediction of the interferon efficacy can be studied through the application of the antigen; thus the inventio