Method of preparing apolipoprotein A-I

The invention belongs to the pharmaceutical field of the biochemical drugs, which relates to the preparation method of the apolipoprotein A-I, in particular to a method for preparing the apolipoprotein A-I (Apo A-I) separated from the waste human plasma F-IV component. The invention adopts the waste...

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Bibliographic Details
Main Authors LIAO XUELING, WU MANPING
Format Patent
LanguageChinese
English
Published 23.01.2008
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The invention belongs to the pharmaceutical field of the biochemical drugs, which relates to the preparation method of the apolipoprotein A-I, in particular to a method for preparing the apolipoprotein A-I (Apo A-I) separated from the waste human plasma F-IV component. The invention adopts the waste human plasma F-IV component to gain the 98 per cent purity through the isoelectric point precipitate, chloroform and ethanol treatment and gain the 23.5 per cent yield based on the calculation of the content of the plasma F-IV Apo A-I, and keeps the apolipoprotein A-I of the natural Apo A-I biological activity; the wet weight/g can prepare 3.1mg purified Apo A-I. The invention lays good foundation for developing the Apo A-I medicinal value and provides a preparation method of human plasma F-IV produced industrially.
Bibliography:Application Number: CN2006129114