Method for preparing unformed Atorvastatin calcium by using crystalline Atorvastatin sodium

This invention discloses a method for preparing amorphous atorvastatin calcium from crystalline atorvastatin sodium. The method comprises: (1) adding crystalline atorvastatin sodium 1 part into a reactor with stirrer, adding water-saturated n-butanol, isobutanol, butanone, 2-methyltetrahydrofuran or...

Full description

Saved in:
Bibliographic Details
Main Authors CHEN ZHIRONG, CHEN ZHENGXU, JIN FANGFEI
Format Patent
LanguageChinese
English
Published 26.12.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:This invention discloses a method for preparing amorphous atorvastatin calcium from crystalline atorvastatin sodium. The method comprises: (1) adding crystalline atorvastatin sodium 1 part into a reactor with stirrer, adding water-saturated n-butanol, isobutanol, butanone, 2-methyltetrahydrofuran or ethyl acetate 30-60 parts, and stirring to obtain a suspension; (2) dropping 3-10% calcium acetate aqueous solution 2.5-5 parts, and stirring for 0.5 -3 h after dropping; (3) standing, separating the water layer, washing the upper layer solution with water 5-10 parts for 2-3 times, and separating the water layer; (4) vacuum-concentrating the upper layer solution to remove the solvent and obtain amorphous atorvastatin calcium. The method has such advantages as no need for filtration, and high yield of amorphous atorvastatin calcium.
Bibliography:Application Number: CN2007169869