2,4 (4,6) pyrimidine derivatives

• Main Authors: ROMBOUTS FREDERIK J. R, FREYNE EDDY JEAN E, EMBRECHTS WERNER C. J, WILLEMS MARC, VAN EMELEN KRISTOF, VAN BRANDT SVEN F. A
• Format: Patent
• Language: Chinese; English
• Published: 22.12.2010
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z and Z represent NH; Y represents -C3-9alkyl-, -C3-9alkenyl-, -C1-5alkyl-NR -C1-5alkyl-, -C1-5alkyl-NR -CO-C1 -5alkyl-, -C1-6alkyl-CO-NH-, -C1-6alkyl-NH-CO-, -C1-2alkyl-CO-Het -CO-, -C1-3alkyl-NH-CO-Het -, -Het -C1-3alkyl-CO-NH-C1-3alkyl-, -C1-2alkyl-NH-CO-L -NH-, -NH-CO-L -NH-, -C1-2alkyl-CO-NH-L -CO-, -C1-2alkyl-NH-CO-L -NH-CO-C1-3alkyl-, -C1-2alkyl-CO-NH-L -CO-NH-C1-3alkyl-, -C1-2alkyl-NR -CH2-CO-NH-C1-3alkyl-, Het -CO-C1-2alkyl-, -C1-5alkyl-CO-NH-C1-3alkyl-CO-NH-, -C1-5alkyl-NR -CO-C1-3alkyl-NH-, -C1-3alkyl-NH-CO-Het -CO-, or -C1-3alkyl-CO-Het -CO-NH-; X represents a direct bond, O, -O-C1-2alkyl-, -CO-C1-2alkyl-, -NR -C1-2alkyl-, -CO-NR -, Het -C1-2alkyl- or C1-2alkyl; X represents a direct bond, O, -O-C1-2alkyl-, -CO-C1-2alkyl-, -NR -C1-2alkyl-, -CO-NR -, Het -C1-2alkyl- or C1-2alkyl; R and R each independently represent h