Deamidated interferon-beta

Interferon-ss protein analogs in which the asparagine at position 25, numbered in accordance with native interferon-ss, is deamidated exhibit a biological activity of native human interferon-ss at an increased level and do not require HA for protein stabilization. The deamidated product is suitable...

Full description

Saved in:
Bibliographic Details
Main Authors JOHNSON-JACKSON DEBORAH, RUSCIO DIANA T, FURUYA KENJI
Format Patent
LanguageChinese
English
Published 09.05.2012
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:Interferon-ss protein analogs in which the asparagine at position 25, numbered in accordance with native interferon-ss, is deamidated exhibit a biological activity of native human interferon-ss at an increased level and do not require HA for protein stabilization. The deamidated product is suitable for large scale manufacturing for incorporation in HA-containing or HA-free therapeutics for treatment of diseases including multiple sclerosis. An endoproteinase-C peptide map technique that produces a fingerprint profile for proteins using an enzymatic digest followed by RP-HPLC is also useful inquality control as an ID and/or quantitative test for the deamidated products.
Bibliography:Application Number: CN200580038118