Method of presuming the metabolism of drug in human liver and liver function

It is intended to provide a method of exactly presuming the metabolism of a drug in the human liver and its effect on the liver function. Namely, a method of presuming the metabolite of a test substance in the human liver and the liver function characterized by comprising administering the test subs...

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Bibliographic Details
Main Author NINOMIYA SHIN ICHI,OHZONE YOSHIYASU,ADACHI YASUHISA,HORIE TORU,SOENO YOSHINORI,INOUE TAE
Format Patent
LanguageEnglish
Published 08.08.2007
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:It is intended to provide a method of exactly presuming the metabolism of a drug in the human liver and its effect on the liver function. Namely, a method of presuming the metabolite of a test substance in the human liver and the liver function characterized by comprising administering the test substance to a nonhuman chimeric animal, which has human-origin hepatocytes having proliferative ability and in which the hepatocytes substantially have the liver functions of the chimeric animal, and a non-chimeric animal of the same species while protecting the animals from the attack by human complements produced by the hepatocytes, and then analyzing and comparing the metabolites of the chimeric animal and the non-chimeric animal.
Bibliography:Application Number: CN200580027396