Method for the preparation of 2'-deoxy-2',2'-difluoro cytidine
This invention relates to an improved method for stereoselectively preparing 2'-deoxy-2',2'-difluorocytidine of formula (I), which comprises the steps of reacting a 1-halo ribofuranose compound of formula (III) with a nucleobase of formula (IV) in a solvent to obtain a nucleoside of f...
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Format | Patent |
Language | English |
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01.08.2007
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Abstract | This invention relates to an improved method for stereoselectively preparing 2'-deoxy-2',2'-difluorocytidine of formula (I), which comprises the steps of reacting a 1-halo ribofuranose compound of formula (III) with a nucleobase of formula (IV) in a solvent to obtain a nucleoside of formula (II) with removing the silyl halide of formula (V) produced during the reaction; and deprotecting the nucleoside of formula (II) to obtain 2'-deoxy-2',2'-difluorocytidine of formula (I). |
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AbstractList | This invention relates to an improved method for stereoselectively preparing 2'-deoxy-2',2'-difluorocytidine of formula (I), which comprises the steps of reacting a 1-halo ribofuranose compound of formula (III) with a nucleobase of formula (IV) in a solvent to obtain a nucleoside of formula (II) with removing the silyl halide of formula (V) produced during the reaction; and deprotecting the nucleoside of formula (II) to obtain 2'-deoxy-2',2'-difluorocytidine of formula (I). |
Author | LEE JAE-HEON,PARK GHA-SEUNG,LEE MOON-SUB,BANG HYO-JEONG,LEE JAE CHUL,KIM CHEOL-KYONG,CHOI CHANG-JU,KIM HAN KYONG,LEE HOE CHUL,CHANG YOUNG-KIL,LEE GWAN SUN |
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Snippet | This invention relates to an improved method for stereoselectively preparing 2'-deoxy-2',2'-difluorocytidine of formula (I), which comprises the steps of... |
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SubjectTerms | CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS |
Title | Method for the preparation of 2'-deoxy-2',2'-difluoro cytidine |
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