Method for the preparation of 2'-deoxy-2',2'-difluoro cytidine
This invention relates to an improved method for stereoselectively preparing 2'-deoxy-2',2'-difluorocytidine of formula (I), which comprises the steps of reacting a 1-halo ribofuranose compound of formula (III) with a nucleobase of formula (IV) in a solvent to obtain a nucleoside of f...
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Main Author | |
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Format | Patent |
Language | English |
Published |
01.08.2007
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Subjects | |
Online Access | Get full text |
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Summary: | This invention relates to an improved method for stereoselectively preparing 2'-deoxy-2',2'-difluorocytidine of formula (I), which comprises the steps of reacting a 1-halo ribofuranose compound of formula (III) with a nucleobase of formula (IV) in a solvent to obtain a nucleoside of formula (II) with removing the silyl halide of formula (V) produced during the reaction; and deprotecting the nucleoside of formula (II) to obtain 2'-deoxy-2',2'-difluorocytidine of formula (I). |
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Bibliography: | Application Number: CN2005829086 |