Alpha and beta poly (L asparamide) amino acid derivatives cisplatin macromolecule prodrug, preparation method and use thereof

The invention discloses a making method and usage of alpha, beta-poly (L-asparagines) amino acid derivant-cisplatin macromolecule fore-drug, which comprises the following steps: blending cisplatin and secondary distill solution of polymer carrier according to different proportions; phosphate under i...

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Bibliographic Details
Main Author JIAHUI,LUO YU
Format Patent
LanguageEnglish
Published 01.08.2007
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses a making method and usage of alpha, beta-poly (L-asparagines) amino acid derivant-cisplatin macromolecule fore-drug, which comprises the following steps: blending cisplatin and secondary distill solution of polymer carrier according to different proportions; phosphate under indoor temperature to stir 48h; dialyzing through secondary distill water until the acidified silver nitrate solution doesn't opacify; obtaining the product to treat solid tumor.
Bibliography:Application Number: CN2007136747