Process for synthesis of thymopentin

This invention is about the synthesis of thymic-pentapeptide. Using tyrosine and its derivative as raw material, after four condensation reactions, we add valine with tertiary-butyl or tertiary-butyl ketonic oxygen group protection, aspartate, lysine, and arginine accordingly to obtain protected pen...

Full description

Saved in:
Bibliographic Details
Main Authors LIU HANGUANG, XIONG WEI, ZOU ZHANGZHONG, XIE WENQUAN
Format Patent
LanguageChinese
English
Published 28.01.2009
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Online AccessGet full text

Cover

More Information
Summary:This invention is about the synthesis of thymic-pentapeptide. Using tyrosine and its derivative as raw material, after four condensation reactions, we add valine with tertiary-butyl or tertiary-butyl ketonic oxygen group protection, aspartate, lysine, and arginine accordingly to obtain protected pentapeptide. With the method we reported here, the all protection groups could be removed once to obtain targeted products, due to our adoption of tertiary-butyl ketonic oxygen group protection strategy. The method is advantageous in simplified procedure, high yield, cost cutting and high purity.
Bibliography:Application Number: CN200510011544