Biphenylmethyl-thiazolidinediones and analogues and their use as PPAR-gamma activators

Biphenyl compounds (I) are new. Biphenyl compounds of formula (I), their optical and geometric isomers and salts when R1 contains a carboxylic acid functional group, are new. R1 = CH2-CH(R6)-C(O)-R5 or a group of formula (i); R2, R3 = NO2 or amino (both optionally substituted by 1-6C alkyl), H, 1-6C...

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Bibliographic Details
Main Authors TERRANOVA ERIC, CLARY LAURENCE
Format Patent
LanguageChinese
English
Published 09.01.2008
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Biphenyl compounds (I) are new. Biphenyl compounds of formula (I), their optical and geometric isomers and salts when R1 contains a carboxylic acid functional group, are new. R1 = CH2-CH(R6)-C(O)-R5 or a group of formula (i); R2, R3 = NO2 or amino (both optionally substituted by 1-6C alkyl), H, 1-6C alkyl, aryl, halo, OR7 or polyether; X = CH2-N(R8)-CO, N(R8)-CO-N(R9), N(R8)-CO-CH2 or N(R8)-CH2-CO; R4 = T, pyrrolyl, pyrazinyl, naphthyl, biphenyl, indolyl, indenyl, benzothienyl, benzofuryl, benzothiazolyl or quinolyl (all optionally substituted by at least one R11 and/or R12), (CH2)n-(CO)qR13, adamantyl, diphenylmethyl, diphenylethyl, diphenylpropyl, diphenylbutyl, cyclopropylmethyl, cyclopentylethyl, 2-benzimidazolyl-ethyl, cyclohexylmethyl, phenoxyphenyl, 9H-fluorenyl, benzyloxyphenyl, 4-heptyloxyphenyl, 4-(6-methyl-2-benzothiazolyl)phenyl or (CH2)n-O-R13; T = phenyl, benzyl, phenethyl, thienyl, furyl or pyridyl (all substituted by R10); R5 = OH or 1-9C alkoxy; R6 = 1-6C alkyl, OR14 or SR14; R7 = H, 1-6C alk
Bibliography:Application Number: CN20028025489