Tablet with controlled release of alfuzosine chlorhydrate

Tablets for oral administration comprise a) a first layer 1 that swells noticeably and rapidly on contact with aqueous biological fluids, the layer being prepared by compression of a mixture or granules having 5 - 90% by weight (pref. 10 - 85%) of hydrophilic polymers, b) a second layer 2 that is ad...

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Bibliographic Details
Main Author JARREAU FRANCOIS XAVIER,VERGNAULT GUY,DUFOUR ALAIN,GRENIER PASCAL,RAUCH-DESANTI CLEMENCE,CONTE UBALDO
Format Patent
LanguageEnglish
Published 05.09.2007
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Tablets for oral administration comprise a) a first layer 1 that swells noticeably and rapidly on contact with aqueous biological fluids, the layer being prepared by compression of a mixture or granules having 5 - 90% by weight (pref. 10 - 85%) of hydrophilic polymers, b) a second layer 2 that is adjacent to or superposed on 1, containing alfuzosin hydrochloride (I), hydrophilic polymers, and auxiliary materials that give the mixture compressibility whilst allowing liberation of (I) over a predetermined period, and optionally c) a third layer 3 that is compressed and applied over 2 which is mainly hydrophilic polymers that gel and/or swell and which may erode, having the effect of modifying liberation of (I) from layer 2, this layer 3 being only slightly permeable to (I) these tablets giving controlled liberation of (I) at the proximal segments of the gastrointestinal tract (duodenum and jejunum).
Bibliography:Application Number: CN200410042295