N-(hidroxialquil (hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio

• Main Authors: Joseph PONTILLO, Christopher WRAY, Bhairavi GALAN, David Matthew SHAW, Stephen Andrew THOMSON, Lidio Marx CARVALHO MEIRELES, Sara S. HADIDA RUAH, Jinglan ZHOU, Ronald Marcellus KNEGTEL, Anisa Nizarali VIRANI, Gorka ETXEBARRIA JARDI, Mary BECK Elizabeth, Robert PULLIN, Steven John DURRANT, Ewa Iwona CHUDYK, Nadia M. AHMAD, Yvonne SCHMIDT, Dennis James HURLEY, Michael Edward O'DONNELL, Joanne Louise PINDER, Timothy Donald NEUBERT, Sarah SKERRATT, James DODD, Kiri NORTH, Dean STAMOS
• Format: Patent
• Language: Spanish
• Published: 24.05.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Se proporcionan compuestos de la fórmula I, y sales farmacéuticamente aceptables de estos, útiles como inhibidores de canales de sodio. También se proporcionan composiciones farmacéuticas que comprenden los compuestos o sales farmacéuticamente aceptables y métodos de uso de los compuestos, sales farmacéuticamente aceptables y composiciones farmacéuticas en el tratamiento de diversos trastornos, incluido el dolor. Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.