Inhibidores heterocíclicos de pad4

• Main Authors: Audrey, Graham ROSS, Ramesh, Kumar SISTLA, Srinivasan THANGATHIRUPATHY, Kumaravel SELVAKUMAR, Vijaya KUMAR CM, Guobin MIAO, Boris M. SELETSKY, Julio Hernán CUERVO, Alyssa H. ANTROPOW, Arul, Mozhi SUBBIAH KARUPPIAH, Daniel S. GARDNER, Mallikarjun, Reddy SURA, T., G. Murali DHAR, Piyush AGARWAL, Paul E. GORMISKY, Deqiang NIU, Robert J. CHERNEY, Manoranjan PANDA, Venkatram Reddy PAIDI, Krishna MAHADEVU, Ooha MORAMPUDI, Tirupathi, Rao ALAJANGI, Zhengdong ZHU, Xiao ZHU, John V. DUNCIA, Jalathi, S. NAIR, Joseph, A. TINO
• Format: Patent
• Language: Spanish
• Published: 24.02.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

La divulgación se refiere generalmente a compuestos heterocíclicos sustituidos de la Fórmula (Ia), que son inhibidores de PAD4, método para preparar estos compuestos, composiciones farmacéuticas que comprenden estos compuestos y uso de estos compuestos en el tratamiento de una enfermedad o trastorno asociado con la actividad de la enzima PAD4. The disclosure generally relates to substituted heterocyclic compounds of Formula (Ia), which are inhibitors of PAD4, method for preparing these compounds, pharmaceutical compositions comprising these compounds and use of these compounds in the treatment of a disease or a disorder associated with PAD4 enzyme activity.