Compuestos 2,3-dihidroquinazolin como inhibidores nav1 .8

• Main Authors: HOANG, Tram H, MILLER, William H, ELBAN, Mark, VIMAL, Mythily, WASHBURN, David G, GUANG, Jie, YING, Maben, DAVIS, Roderick S, HO, Ming-Hsun, ROMANO, Joseph J
• Format: Patent
• Language: Spanish
• Published: 21.04.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

COMPUESTOS DERIVADOS DE 2,3-DIHIDROQUINAZOLIN COMO INHIBIDORES NAV1 .8; COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENE Y EL USO EN EL TRATAMIENTO DEL DOLOR. The present invention relates to Nav1.8 Inhibitor 2,3-dihydroquinazolin compounds of Formula (X):wherein Y′, X′, B′, R1′, R2′, R3′, R5′, R6′, R7′, and z1 are as defined herein; or pharmaceutically acceptable salts or tautomer forms thereof, corresponding pharmaceutical compositions or formulations, methods or processes of compound preparation, methods, compounds for use in, uses for and/or combination therapies for treating pain and/or pain-related or associated disease(s), disorder(s) or condition(s), respectively.