Compuestos derivados de macrociclos, inhibidores del factor xia composición farmacéutica que los comprende y su uso en el tratamiento yo profilaxis de una enfermedad tromboembolica. pct

LA SOLICITUD SE REFIERE A COMPUESTOS DERIVADOS DE MACROCICLOS, INHIBIDORES DEL FACTOR XIA, A UNA COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE Y A SU USO EN EL TRATAMIENTO YO PROFILAXIS DE UNA ENFERMEDAD TROMBOEMBOLICA. The present invention provides compounds of Formula (I):or stereoisomers, tautomers...

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Main Authors SMITH LEON M. II, WEXLER RUTH R, ZHU YEHENG, ORWAT MICHAEL J, PINTO DONALD J.P, DE LUCCA INDAWATI, PABBISETTY KUMAR BALASHANMUGA, FANG TIANAN, WANG YUFENG, DILGER ANDREW K, EWING WILLIAM R, YANG WU, CORTE JAMES R
Format Patent
LanguageSpanish
Published 24.03.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:LA SOLICITUD SE REFIERE A COMPUESTOS DERIVADOS DE MACROCICLOS, INHIBIDORES DEL FACTOR XIA, A UNA COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE Y A SU USO EN EL TRATAMIENTO YO PROFILAXIS DE UNA ENFERMEDAD TROMBOEMBOLICA. The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and these compounds for use in therapy.
Bibliography:Application Number: CL20160001933