Inhibidores macrocíclicos de las interacciones proteína/proteína pd-1/pd-l1 y cd80(b7-1)/pd-l1

PÉPTIDOS MACROCÍCLICOS INHIBIDORES DE LAS INTERACCIONES PROTEÍNA PD-1/PD-L1 Y CD80(B7-1)/PD-L1; Y USO PARA MEJORAR LA RESPUESTA INMUNE, INHIBIR CRECIMIENTO DE CÉLULAS CANCERÍGENAS Y TRATAR ENFERMEDAD INFECCIOSA. The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1...

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Main Authors MULL ERIC, ZHU JULIANG, SCOLA PAUL MICHAEL, BOY KENNETH M, YEUNG KAP-SUN, BOWSHER MICHAEL S, SANGHVI NISHITH, REID PATRICK C, SUN LI-QIANG, MILLER MICHAEL MATTHEW, TENNEY DANIEL J, POIRIER MAUDE A, GILLIS ERIC P, LANGLEY DAVID R, MAPELLI CLAUDIO, ALLEN MARTIN PATRICK
Format Patent
LanguageSpanish
Published 28.03.2016
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Summary:PÉPTIDOS MACROCÍCLICOS INHIBIDORES DE LAS INTERACCIONES PROTEÍNA PD-1/PD-L1 Y CD80(B7-1)/PD-L1; Y USO PARA MEJORAR LA RESPUESTA INMUNE, INHIBIR CRECIMIENTO DE CÉLULAS CANCERÍGENAS Y TRATAR ENFERMEDAD INFECCIOSA. The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Bibliography:Application Number: CL20150002709