Dispersion solida fisicamente estable del acido 4-{[(2r,3s,4r,5s)-4-(4-cloro-2-fluorofenil)-4-ciano-5-(2,2-dimetilpropil)-pirrolidin-2-carbonil]-amino}-3-metoxibenzoico; formulacion solida; metodo de preparacion; preparacion farmaceutica; uso para tratar el cancer, en particular leucemia mieloide aguda o cancer de prostata

The invention relates to solid dispersions of poorly water soluble compounds, in particular Compound A as disclosed herein, formed by solvent co-precipitation or spray drying, resulting in improved bioavailability, safety and tolerability of said compounds.

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Bibliographic Details
Main Authors SHAH NAVNIT HARGOVINDAS, MA HUA, ZHANG YU-E, LOMUSCIO STEVE, MATCHETT MICHAEL ALLEN, SANDHU HARPREET K
Format Patent
LanguageSpanish
Published 23.10.2015
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to solid dispersions of poorly water soluble compounds, in particular Compound A as disclosed herein, formed by solvent co-precipitation or spray drying, resulting in improved bioavailability, safety and tolerability of said compounds.
Bibliography:Application Number: CL20150001649