Inhibidores de glucosilceramida sintasa

COMPUESTOS 1-AZABICICLO SUSTITUIDOS, INHIBIDORES DE GLUCOSIL CERAMIDA SINTASA (GCS); COMPOSICION FARMACEUTICA; METODO PARA TRATAR CANCER, TRASTORNO METABOLICO, ENFERMEDAD NEUROPATICA Y ENFERMEDAD ASOCIADA A ALMACENAMIENTO LISOSOMAL; Y METODO PARA DISMINUIR LA ACTIVIDAD CATALITICA GLUCOSILCERAMIDA SI...

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Main Authors GOOD ANDREW, ZHAO ZHONG, SKERLJ RENATO, NATOLI THOMAS, XIANG YIBIN, METZ MARKUS, CABRERA-SALAZAR MARIO A, BESKROVNAYA OXANA, MAKINO ELINA, CELATKA CASSANDRA, MARSHALL JOHN, SCHEULE RONALD K, HIRTH BRADFORD, LEONARD JOHN, HUSSON HERVE, JANCSICS KATHERINE, BOURQUE ELYSE, CHENG SENG H
Format Patent
LanguageSpanish
Published 13.11.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:COMPUESTOS 1-AZABICICLO SUSTITUIDOS, INHIBIDORES DE GLUCOSIL CERAMIDA SINTASA (GCS); COMPOSICION FARMACEUTICA; METODO PARA TRATAR CANCER, TRASTORNO METABOLICO, ENFERMEDAD NEUROPATICA Y ENFERMEDAD ASOCIADA A ALMACENAMIENTO LISOSOMAL; Y METODO PARA DISMINUIR LA ACTIVIDAD CATALITICA GLUCOSILCERAMIDA SINTASA EN UNA CELULA IN VITRO. The invention relates to inhibitors of glucosylceramide synthase (GCS) of formula (I) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
Bibliography:Application Number: CL20150000529