Compuestos derivados de 3-metil-7-oxo-4-tia-1-aza-biciclo[3.2.0]heptano para utilizarse en la inhibicion de beta-lactamasas producidas por bacterias y restaurar/potenciar la actividad de antibioticos; y composicion farmaceutica que los comprende

Described herein are compounds and their use in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as beta-lact...

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Main Authors APPU, ARAVIND, UDAYAMPALAYAM PALANISAMY, SENTHILKUMAR, NARAYANAN, SHRIDHAR, MANICKAM, SENTHILNATHAN, PAUL-SATYASEELA, MANEESH, BALASUBRAMANIAN, GOPALAN, PERIASAMY, HARIHARAN
Format Patent
LanguageSpanish
Published 04.04.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Described herein are compounds and their use in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as beta-lactamase inhibitors, which restore or enhance the antibiotic spectrum of a suitable antibiotic agent. The compounds of formula (I) act as inhibitors of beta-lactamases. These compounds restore/potentiate the activities of beta-lactam antibiotics against carbapenemases. These compounds find use in diagnostic method for detecting beta-lactamases. Formula (I)
Bibliography:Application Number: CL20130001482