Compuestos derivados de heerociclos sustituidos, inductores de apoptosis; composicion farmaceutica; y su uso para el tratamiento de diversos cancer, tales como vejiga, cerebro, mamas, medula osea, hepatocelular, linfoma, leucemia linfoblastica, entre otros

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

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Bibliographic Details
Main Authors TAO ZHI-FU, WANG GARY, HASVOLD LISA, HANSEN TODD M, WANG LE, SONG XIAOHONG, DOHERTY GEORGE, MANTEI ROBERT, BRUNCKO MILAN, SULLIVAN GERARD, KUNZER AARON, SOUERS ANDREW J, WANG XILU, WENDT MICHAEL, ELMORE STEVEN, DING HONG, HEXAMER LAURA
Format Patent
LanguageSpanish
Published 21.02.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Bibliography:Application Number: CL20120003286