COMPUESTOS DERIVADOS DE HETEROCICLOS SUSTITUIDOS CON MORFOLINA, INHIBIDORES DE LA ACTIVIDAD PI3 QUINASA; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; KIT FARMACEUTICO; Y SU USO PARA EL TRATAMIENTO PROFILACTICO O TERAPEUTICO DEL CANCER

Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R 3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases i...

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Main Author BAYLISS TRACY,CHUCKOWREE IRINA,FOLKES ADRIAN,OXENFORD SALLY,WAN NAN CHI,CASTANEDO GEORGETTE,GOLDSMITH RICHARD,GUNZNER JA
Format Patent
LanguageSpanish
Published 22.08.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R 3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Bibliography:Application Number: CL20070003520