COMPUESTOS DERIVADOS DE AZABENZOTIOFENIL; COMPOSICION FARMACEUTICA; Y USO PARA LA INHIBICION DEL CRECIMIENTO CELULAR ANOMALO O DE TRATAMIENTO DE UN TRASTORNO HIPERPROLIFERATIVO

The invention relates to azabenzothiophenyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzothiophenyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or...

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Bibliographic Details
Main Author PRICE, STEPHEN; WILLIAMS, KAREN; SAVY, PASCAL PIERRE; DYKE, HAZEL JOAN; MONTANA, JOHN GARY; STANLEY, MARK S.; BAO, LIANG
Format Patent
LanguageSpanish
Published 14.03.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to azabenzothiophenyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzothiophenyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
Bibliography:Application Number: CL20070002431