COMPUESTOS DERIVADOS DE BENCENOSULFONAMIDA, SUS SALES; COMPOSICION FARMACEUTICA, Y SU USO EN EL TRATAMIENTO DE UNA ENFERMEDAD RELACIONADA CON CCR3, TALES COMO ASMA, DERMATITIS ATOPICA, RINITIS, VIH, GRANULOMA PULMONAR, ALZHEIMER

The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the p...

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Main Author YINGFU LI;KEVIN BACON;HIROMI SUGIMOTO;KEIKO FUKOSHIMA; KENTARO HASHIMOTO;MAKIKO MARUMO;TOSHIYA MORIWAKI;NORIKO NUNA
Format Patent
LanguageSpanish
Published 04.02.2005
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of disease associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. wherein X represents O or S; R 4 represents the other substituents are as defined in claim 1.
Bibliography:Application Number: CL20040000626