PYRIDO(3,4-E)-AS-TRIAZIN-DERIVATE UND VERFAHREN ZU DEREN HERSTELLUNG

• Main Authors: HRISZTONE TONCSEV, JUDIT TIMAR-GERGELY, LUJZA PETOECZ, PETER GOEROEG, ENIKOE SZIRT-KISZELLY, IBOLYA KOSOCZKY, GYOERGYI KOVANYI-LAX, PAL BENKO, MARIA SIGMOND-LAKATOS
• Format: Patent
• Language: German
• Published: 31.07.1984
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Acylated pyrido [3,4-e]-as-triazines of the formula (I), (I) wherein R1 stands for alkyl, alkoxy, haloalkyl, furyl, pyridyl, phenyl, phenyl-(C1-4alkyl) or phyenyl-(C2-4 alkenyl) optionally substituted. R2 stands for hydrogen or a group of the formula R1-CO-, R3 stands for hydrogen, a phenyl group or a naphthy6l group optionally substituted, or a phenyl-(C1-4alkyl) group, pyridyl group or a C1-20alkyl group, and R4 stands for hydrogen or a group of the formula R1-CO-, and R5 forms together with R2 or R4 a valence bond, wherein R2 or R4 taking part in forming said valence bond may not have the above meaning, and pharmaceutically acceptable acid addition salts thereof, which are prepared by reacting a pyrido [3,4-e]-as-triazine of the formula (II) or an acid addition salt thereof (II) R6 stands for hydrogen, and R5 forms together with Rand R4 a valence bond, with an acylating agent of the formula (III). R1-CO-X (III) The compounds exert favourable effects on the central nervous system, and can be applied primarily as analgesic and antiphlogistic agents.