2-thiacephalosporanic acid derivs - useful as pharmaceuticals and intermediates

Cpds. of formula (I): (where Ra1 = Hb or an N-protecting gp; Rb1 = H or Ra1 + Rb1 = an org. ylidene gp. R2 = H or an ester-forming goup (RA2); R3 = H or a C-bonded org. gp. Ra and Rb are H or from a C-C bond) and their S-oxides and salts are prepd. by oxidn. of a cpd. (II) or acid treatment of a cpd...

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Bibliographic Details
Main Author WOODWARD,ROBERT BURNS
Format Patent
LanguageEnglish
German
Published 15.09.1973
Edition1
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Cpds. of formula (I): (where Ra1 = Hb or an N-protecting gp; Rb1 = H or Ra1 + Rb1 = an org. ylidene gp. R2 = H or an ester-forming goup (RA2); R3 = H or a C-bonded org. gp. Ra and Rb are H or from a C-C bond) and their S-oxides and salts are prepd. by oxidn. of a cpd. (II) or acid treatment of a cpd. (III) where X = opt. substd. methylene; R1o = H or a removable org. gp; RB2 = RA2 or an org. silyl orstannyl gp; Aco1 is a removable acyl gp) opt. followed by removal of the ylidene gp, saponification, esterification, conversion into the S-oxide and/or salt formation. (I) are pharmaceuticals or intermediates therefor e.g. (I) where Ra1 is an N-acyl deriv. of a penicillin or cephalosporin cpd. are broad-spectrum antibacterial.
Bibliography:Application Number: CH19730004920