3-enol ethers and esters of 1alpha 2alpha

Compounds of general formula (I): (I) R1 = acyl, alkyl, aryl, aralkyl, or cycloalkyl R2 = acyl or (R' not acyl) H (a) Anabolics with good anabolic/androgenic ratio (Q). (Q) detd. by hevator ani and seminal vesicle assays on castrated male rats:- Q I (R1=R2=MeCO) 10 1-methyl androst-1-ene- -3- 5...

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Bibliographic Details
Main Author WIECHERT,RUDOLF,DR
Format Patent
LanguageEnglish
German
Published 30.09.1972
Edition1
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
STEROIDS
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Summary:Compounds of general formula (I): (I) R1 = acyl, alkyl, aryl, aralkyl, or cycloalkyl R2 = acyl or (R' not acyl) H (a) Anabolics with good anabolic/androgenic ratio (Q). (Q) detd. by hevator ani and seminal vesicle assays on castrated male rats:- Q I (R1=R2=MeCO) 10 1-methyl androst-1-ene- -3- 5 one-17-acetate Testosterone propionate 1 Higher esters of I (e.g. 17 enanthate) have a prolonged effect. (b) Ovulation inhibitors. I administered to female rats in varying doses, and compared with known active cpds. WD50 is dose reqd. in mg/animal/day to prevent ovulation for 4 consecutive days.
Bibliography:Application Number: CH19640008696