Tricyclic cpds antidepressive
(A) Cpds. of general formula (I) Including salts, and stereoisomers of I. R' = H or Me R = Me or MeCO (B) N-oxides of I (R' = Me). Antidepressants, adrenolytics, antihistamines, and local anaesthetics, with low toxicity and slight anticholinergic activity. 1-Methyl-10,11-dihydro-(3-dimethy...
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| Main Authors | , |
|---|---|
| Format | Patent |
| Language | English German |
| Published |
15.10.1971
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| Edition | 1 |
| Subjects | |
| Online Access | Get full text |
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| Abstract | (A) Cpds. of general formula (I) Including salts, and stereoisomers of I. R' = H or Me R = Me or MeCO (B) N-oxides of I (R' = Me). Antidepressants, adrenolytics, antihistamines, and local anaesthetics, with low toxicity and slight anticholinergic activity. 1-Methyl-10,11-dihydro-(3-dimethylamino-propylidene) 5H-dibenzo(a,d)cycloheptene (39.5 g), was hydrogenated at 25 deg./1 atm., over Pt2O (3 g.) in AcOH (400 ml). The mixture was filtered, evapd. and the residue distilled, giving the 3-dimethylaminopropyl deriv., b.p.140 deg./0.01 mm. (Hydrochloride m.p.181-3 deg., from Et2O-EtOH). |
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| AbstractList | (A) Cpds. of general formula (I) Including salts, and stereoisomers of I. R' = H or Me R = Me or MeCO (B) N-oxides of I (R' = Me). Antidepressants, adrenolytics, antihistamines, and local anaesthetics, with low toxicity and slight anticholinergic activity. 1-Methyl-10,11-dihydro-(3-dimethylamino-propylidene) 5H-dibenzo(a,d)cycloheptene (39.5 g), was hydrogenated at 25 deg./1 atm., over Pt2O (3 g.) in AcOH (400 ml). The mixture was filtered, evapd. and the residue distilled, giving the 3-dimethylaminopropyl deriv., b.p.140 deg./0.01 mm. (Hydrochloride m.p.181-3 deg., from Et2O-EtOH). |
| Author | SPIEGELBERG,HANS,DR KYBURZ,EMILIO,DR |
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| Discipline | Medicine Chemistry Sciences |
| DocumentTitleAlternate | Verfahren zur Herstellung von tricyclischen Verbindungen |
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| Notes | Application Number: CH19700017685 |
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| PublicationDate | 19711015 |
| PublicationDateYYYYMMDD | 1971-10-15 |
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| PublicationDecade | 1970 |
| PublicationYear | 1971 |
| RelatedCompanies | F. HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT |
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| Snippet | (A) Cpds. of general formula (I) Including salts, and stereoisomers of I. R' = H or Me R = Me or MeCO (B) N-oxides of I (R' = Me). Antidepressants,... |
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| Title | Tricyclic cpds antidepressive |
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