Tricyclic cpds antidepressive

(A) Cpds. of general formula (I) Including salts, and stereoisomers of I. R' = H or Me R = Me or MeCO (B) N-oxides of I (R' = Me). Antidepressants, adrenolytics, antihistamines, and local anaesthetics, with low toxicity and slight anticholinergic activity. 1-Methyl-10,11-dihydro-(3-dimethy...

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Bibliographic Details
Main Authors SPIEGELBERG,HANS,DR, KYBURZ,EMILIO,DR
Format Patent
LanguageEnglish
German
Published 15.10.1971
Edition1
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:(A) Cpds. of general formula (I) Including salts, and stereoisomers of I. R' = H or Me R = Me or MeCO (B) N-oxides of I (R' = Me). Antidepressants, adrenolytics, antihistamines, and local anaesthetics, with low toxicity and slight anticholinergic activity. 1-Methyl-10,11-dihydro-(3-dimethylamino-propylidene) 5H-dibenzo(a,d)cycloheptene (39.5 g), was hydrogenated at 25 deg./1 atm., over Pt2O (3 g.) in AcOH (400 ml). The mixture was filtered, evapd. and the residue distilled, giving the 3-dimethylaminopropyl deriv., b.p.140 deg./0.01 mm. (Hydrochloride m.p.181-3 deg., from Et2O-EtOH).
Bibliography:Application Number: CH19700017685