Verfahren zur Herstellung wasserlöslicher Derivate von Tetracyclinen

A water-soluble derivative of a tetracycline is prepared by treating an aqueous suspension of a tetracycline with formaldehyde at a pH value between 5 and 9. The tetracycline may be tetracycline itself, chlorotetracycline, oxytetracycline or demethylchlorotetracycline. The formaldehyde may be added...

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Bibliographic Details
Main Authors BANCI,FERIANO,DR, TUBARO,EZIO,DR
Format Patent
LanguageGerman
Published 15.03.1966
Edition1
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A water-soluble derivative of a tetracycline is prepared by treating an aqueous suspension of a tetracycline with formaldehyde at a pH value between 5 and 9. The tetracycline may be tetracycline itself, chlorotetracycline, oxytetracycline or demethylchlorotetracycline. The formaldehyde may be added in aqueous solution, in gaseous form or as paraldehyde, and the soluble product may be separated by lyophilization or by precipitation with a mixture of water-miscible organic solvents.
Bibliography:Application Number: CH19610003654