Procédé de préparation de 2-guanidino-3,4-dihydroquinazolines

The invention comprises compounds of the general formula: <FORM:0952891/C2/1> (wherein R represents a hydrogen atom or a chlorine or bromine atom in the 5-, 6- or 7-position and R1, R2 and R3 each independently represent a hydrogen atom or an aliphatic hydrocarbon radical of up to 6 carbon ato...

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Bibliographic Details
Main Authors DOUB,LEONARD, M. RICHARDSON,LUCILLE, CAMPBELL,ALFRED
Format Patent
LanguageFrench
Published 15.07.1965
Edition1
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention comprises compounds of the general formula: <FORM:0952891/C2/1> (wherein R represents a hydrogen atom or a chlorine or bromine atom in the 5-, 6- or 7-position and R1, R2 and R3 each independently represent a hydrogen atom or an aliphatic hydrocarbon radical of up to 6 carbon atoms) and their acid addition salts, the preparation thereof by reacting a 1-aminoethyl -2- aminobenzene of the general formula: <FORM:0952891/C2/2> acid addition salt form or in the presence of acid with a dicyandiamide of the general formula: <FORM:0952891/C2/3> at elevated temperature in the presence of an aqueous solvent, and pharmaceutical compositions containing the products in association with a pharmaceutical diluent or excipient. 1-Aminomethyl -2- aminobenzenes of the second general formula above are prepared by reducing the corresponding anthranilamides by means of lithium aluminium hydride. The pharmaceutical compositions, which have psychodynamic (e.g. anti-reserpine) activity, are preferably in unit dosage forms suitable for oral administration. Salts specified include the ascorbates.
Bibliography:Application Number: CH19610000129