METHOD FOR CONTROLLING EMESIS WITH N-(1-SUBSTITUTED-3-PYRROLIDINYL) BENZAMIDES AND THIOBENZAMIDES

Title cpds. are of formulae (I) and (II): where R = 4-12C cycloalkyl, opt. substd. Ph, or phenyl-alkyl; R1 = H, 1-8C alkyl, or opt. substd. Ph; R2 = Hal, 1-8C alkyl, 1-8C alkoxy, NH2, NH alkyl, N(alkyl)2, NO2, CH3S-, CH3CONH, sulphamoyl, CN, OH, PhCH2O-, or CF3; R3 = 4-12c cycloalkyl; R4 = H or 1-8C...

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Bibliographic Details
Main Authors CALE, ALBERT D. (JR.), LEONARD, CHARLES A
Format Patent
LanguageEnglish
Published 26.10.1976
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Title cpds. are of formulae (I) and (II): where R = 4-12C cycloalkyl, opt. substd. Ph, or phenyl-alkyl; R1 = H, 1-8C alkyl, or opt. substd. Ph; R2 = Hal, 1-8C alkyl, 1-8C alkoxy, NH2, NH alkyl, N(alkyl)2, NO2, CH3S-, CH3CONH, sulphamoyl, CN, OH, PhCH2O-, or CF3; R3 = 4-12c cycloalkyl; R4 = H or 1-8C alkyl; R5 = NH2, NO2, hal, sulphamoyl, or 1-8C alkoxy; and n = 0-3. (I) are prepd. e.g., by condensing a 3-aminopyrrolidine with a benzoyl chloride or with a benzaldehyde and S and opt. heating (I) with K2S/P2S5 to give (II).
Bibliography:Application Number: CA19730167654