PROCESS FOR THE MANUFACTURE OF 3 -HYDROXY-5 -CARDENOLIDES

1327438 Henbest reduction of 3-oxocardenolides FARBWERKE HOECHST AG 13 Nov 1970 [14 Nov 1969] 54261/70 Heading C2U 3# - Hydroxy - 5# - card - 20(22) - enolides are prepared by reduction of the corresponding 3-oxo-compounds using a trialkyl phosphite and a C 1-4 alcohol together with H 2 IrCl 6 or an...

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Bibliographic Details
Main Authors RADSCHEIT K, STACHE U, HAEDE W, FRITSCH W
Format Patent
LanguageEnglish
Published 13.03.1973
Subjects
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
STEROIDS
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:1327438 Henbest reduction of 3-oxocardenolides FARBWERKE HOECHST AG 13 Nov 1970 [14 Nov 1969] 54261/70 Heading C2U 3# - Hydroxy - 5# - card - 20(22) - enolides are prepared by reduction of the corresponding 3-oxo-compounds using a trialkyl phosphite and a C 1-4 alcohol together with H 2 IrCl 6 or an alkali metal or ammonium salt thereof or IrCl 3 , and optionally with the addition of a mineral acid (e.g. HCl). Minor amounts of the 3α-hydroxy epimers may also be obtained. Specified products are digitoxigenin, 14- anhydrodigitoxigenin and 3-epi-14-anhydrodigitoxigenin.
Bibliography:Application Number: CA19700098045