SINGLE DOMAIN ANTIBODIES FOR PREVENTION OF CLOSTRIDIUM DIFFICILE INFECTION

The present disclosure relates to single domain antibodies which binds to Clostridium difficile toxin B and their use in the treatment and prevention of Clostridium difficile infection. Further disclosed are nucleic acids and vectors encoding the single domain antibodies, host cells for expression o...

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Main Authors RODRIGUEZ-RODRIGUEZ, EVERARDO, LAUSTSEN, ANDREAS HOUGAARD, LAUSTSEN, MADS AAGE, THRANE, SANDRA WINGAARD
Format Patent
LanguageEnglish
French
Published 08.06.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Summary:The present disclosure relates to single domain antibodies which binds to Clostridium difficile toxin B and their use in the treatment and prevention of Clostridium difficile infection. Further disclosed are nucleic acids and vectors encoding the single domain antibodies, host cells for expression of the single domain antibodies, methods of manufacture and compositions. La présente invention concerne des anticorps à domaine unique qui se lient à la toxine B du Clostridium difficile et leur utilisation dans le traitement et la prévention d'une infection à Clostridium difficile. L'invention concerne en outre des acides nucléiques et des vecteurs codant pour les anticorps à domaine unique, des cellules hôtes pour l'expression des anticorps à domaine unique, des procédés de fabrication et des compositions.
Bibliography:Application Number: CA20223238720