ANTI-APOPTOTIC PROTEIN BCL-2 INHIBITOR, PHARMACEUTICAL COMPOSITION AND USES THEREOF

Disclosed is a BCL-2 protein apoptosis inducer, and further disclosed are the uses of the compound and a pharmaceutical composition comprising the compound in the preparation of a drug for treating diseases related to anti-apoptotic protein BCL-2. The compound has potent BCL-2/BAK blocking activity,...

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Main Authors ZHU, JIANRONG, HU, MIAO, SU, MINGBO, JING, HANGHUI, LIU, XINGGUO, HUANG, JINGLAI, WU, YIZHE, ZHONG, LI, GAO, ANHUI, ZHOU, XINGLU
Format Patent
LanguageEnglish
French
Published 15.06.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Disclosed is a BCL-2 protein apoptosis inducer, and further disclosed are the uses of the compound and a pharmaceutical composition comprising the compound in the preparation of a drug for treating diseases related to anti-apoptotic protein BCL-2. The compound has potent BCL-2/BAK blocking activity, and can be used for treating diseases such as infectious diseases, immune diseases, inflammatory diseases or cell proliferation abnormalities that benefit from the inhibition of anti-apoptotic protein BCL-2. L'invention concerne un inducteur de l'apoptose de la protéine BCL-2, ainsi que des utilisations du composé et une composition pharmaceutique comprenant le composé dans la préparation d'un médicament pour le traitement de maladies associées à la protéine BCL-2 anti-apoptotique. Le composé a une puissante activité de blocage de BCL-2/BAK, et peut être utilisé pour traiter des maladies telles que des maladies infectieuses, des maladies immunitaires, des maladies inflammatoires ou des anomalies de prolifération cellulaire qui bénéficient de l'inhibition de la protéine BCL-2 anti-apoptotique.
Bibliography:Application Number: CA20223238433