CRYSTALLINE FORM TYPE 5 OF SUGAMMADEX

• Main Authors: AVALLE, PAOLO, SCHOELL, JOCHEN, LAMBERTO, DAVID J, NEUHAUS, JEFFREY S, CODAN, LORENZO, LARPENT, PATRICK
• Format: Patent
• Language: English; French
• Published: 25.06.2024
• Subjects: AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUSPOLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR; CHEMISTRY; COMPOSITIONS BASED THEREON; CRYSTAL GROWTH; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITHDEFINED STRUCTURE; REFINING BY ZONE-MELTING OF MATERIAL; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITHDEFINED STRUCTURE; SINGLE-CRYSTAL-GROWTH; THEIR PREPARATION OR CHEMICAL WORKING-UP; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL ORUNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL

The present invention relates to crystalline form Type 5 of sugammadex, to uses thereof, and to related pharmaceutical compositions. The crystalline form may be used, for example, in the preparation of a medicament comprising sugammadex for reversing neuromuscular blockade induced by rocuronium and/or vecuronium in patients (e.g., adults, children) undergoing surgery. La présente invention concerne un procédé de séchage de sugammadex cristallin pour satisfaire à des spécifications de solvant qui sont indépendantes de la cristallinité de lingrédient actif ou de la forme cristalline générée. Linvention concerne en outre lutilisation de sugammadex dans linversion du blocage neuromusculaire induit par le bromure de rocuronium ou par le bromure de vécuronium chez les adultes soumis une chirurgie.