IMMUNOMODULATING AZALIDES

Defined herein are immunomodulating Formula (1) compounds, wherein R, R0, R1, R2 and W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating or preventing an inflammato...

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Bibliographic Details
Main Authors HOT, IMELDA, COX, MARK R, EWIN, RICHARD A, MADDUX, TODD M, RESPONDEK, TOMASZ
Format Patent
LanguageEnglish
French
Published 16.03.2023
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:Defined herein are immunomodulating Formula (1) compounds, wherein R, R0, R1, R2 and W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating or preventing an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, or pharmaceutically acceptable salt thereof; or use of said Formula (1) compound to prepare a medicament for treating or preventing an inflammatory and/or immunological disease or disorder in an animal. La présente invention concerne des composés immunomodulateurs de formule (1), R, R0, R1, R2 et W étant tels que définis dans la description, des stéréoisomères et des sels pharmaceutiquement acceptables de ceux-ci; ainsi que des compositions comprenant lesdits composés. L'invention concerne également des méthodes de traitement d'une maladie ou d'un trouble inflammatoire et/ou immunologique chez un animal par administration d'une quantité thérapeutiquement efficace du composé de formule (1), un stéréoisomère, ou un sel pharmaceutiquement acceptable de celui-ci; ou l'utilisation dudit composé de formule (1) pour préparer un médicament pour traiter ou prévenir une maladie ou un trouble inflammatoire et/ou immunologique chez un animal.
Bibliography:Application Number: CA20223231535