ORGANOID-DERIVED MONOLAYERS AND USES THEREOF

The invention relates to culture methods, in particular methods of obtaining organoid-derived monolayers, and to uses of the organoid-derived monolayers obtained by said methods. The invention also relates to assays for epithelial barrier function and methods of screening compounds using said assays...

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Main Authors VRIES, ROBERT GERHARDUS JACOB, MERENDA, ALESSANDRA, DERKSEN, MEREL, FERNANDEZ-BOJ, SYLVIA, POURFARZAD, FARZIN
Format Patent
LanguageEnglish
French
Published 12.01.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PHYSICS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:The invention relates to culture methods, in particular methods of obtaining organoid-derived monolayers, and to uses of the organoid-derived monolayers obtained by said methods. The invention also relates to assays for epithelial barrier function and methods of screening compounds using said assays. L'invention concerne des procédés de culture, en particulier des procédés d'obtention de monocouches dérivées d'organoïdes, ainsi que des utilisations des monocouches dérivées d'organoïdes obtenues selon lesdits procédés. L'invention concerne également des dosages pour la fonction de barrière épithéliale et des procédés de criblage de composés à l'aide desdits dosages.
Bibliography:Application Number: CA20223226188