SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS

• Main Authors: GEDDIS, STEPHEN MICHAEL, AHMAD, NADIA M, STEVENS, REBECCA E, PULLIN, ROBERT, GALAN, BHAIRAVI, HURLEY, DENNIS JAMES, THOMSON, STEPHEN ANDREW, MUI, JAMES JUN BON, PONTILLO, JOSEPH, DODD, JAMES, KINTZER, ALEXANDER, CHUDYK, EWA IWONA, TWIN, HEATHER CLARE, JACQUES, REECE, ETXEBARRIA JARDI, GORKA, SKERRATT, SARAH, PINDER, JOANNE LOUISE, NORTH, KIRI, STAMOS, DEAN, ZHOU, JUNGLAN, SCHMIDT, YVONNE, SHAW, DAVID MATTHEW, WRIGHT, MIRANDA ADELE, HADIDA RUAH, SARA, DURRANT, STEVEN JOHN, NEUBERT, TIMOTHY DONALD, VIRANI, ANISA NIZARALI, SOUSA, BRUNO ARTUR, CARVALHO MEIRELES, LIDIO MARX, BECK, ELIZABETH MARY, KNEGTEL, RONALD MARCELLUS, MILLER, MARK THOMAS, WRAY, CHRISTOPHER
• Format: Patent
• Language: English; French
• Published: 08.12.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds of formula I and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain. L'invention concerne des composés de formule I et des sels pharmaceutiquement acceptables de ceux-ci, utiles en tant qu'inhibiteurs de canaux sodiques. L'invention concerne également des compositions pharmaceutiques comprenant ces composés ou ces sels pharmaceutiquement acceptables et des procédés d'utilisation de ces composés, de ces sels pharmaceutiquement acceptables et de ces compositions pharmaceutiques dans le traitement de divers troubles, notamment de la douleur.