AGENTS FOR DIRECTED CONJUGATION TECHNIQUES AND CONJUGATED PRODUCTS

Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high conjugation efficiency and selectivity. In some embodiments, p...

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Bibliographic Details
Main Authors DUBOWCHIK, GENE M, CALDWELL, REESE M, KAZMIERSKI, WIESLAW, SPIEGEL, DAVID ADAM
Format Patent
LanguageEnglish
French
Published 24.11.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high conjugation efficiency and selectivity. In some embodiments, provided technologies are useful for preparing antibody conjugates. Entre autres, la présente invention concerne des technologies de conjugaison dirigée sur site de diverses fractions d'intérêt à des agents cibles. Dans certains modes de réalisation, la présente invention utilise des fractions de liaison cibles pour assurer une efficacité de conjugaison et une sélectivité élevées. Dans certains modes de réalisation, des technologies fournies sont utiles pour préparer des conjugués d'anticorps.
Bibliography:Application Number: CA20223219517