3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND MEDICAL USES THEREOF

The application relates to compounds of formula (I), pharmaceutical compositions comprising them and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobin...

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Main Authors BONAZZI, SIMONE, CERNIJENKO, ARTIOM, COBB, JENNIFER STROKA, DEWHURST, JANETTA, O'BRIEN, GARY, KERRIGAN, JOHN RYAN, THOMSEN, NOEL MARIE-FRANCE, TING, PAMELA YF, SUNG, MOOJE
Format Patent
LanguageEnglish
French
Published 08.12.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The application relates to compounds of formula (I), pharmaceutical compositions comprising them and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta- hemoglobinopathies), such as sickle cell disease and beta- thalassemia. La demande concerne des composés de formule (I), des compositions pharmaceutiques les comprenant et leur utilisation dans la réduction des niveaux d'expression de motifs en doigts de zinc largement espacés (WIZ), ou l'induction de l'expression de l'hémoglobine ftale (HbF), et dans le traitement de troubles du sang hérités (par exemple, des hémoglobinopathies, par exemple, des bêta-hémoglobinopathies), tels que la drépanocytose et la bêta-thalassémie.
Bibliography:Application Number: CA20223215410