3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONES AS MEK INHIBITORS

• Main Authors: KELLUM, ALEX ANDREW, BLANCHE, SYDNEY TAYLOR, FULTON, JENNIFER LYNN, REN, LI, DOERNER BARBOUR, PATRICK MICHAEL, MORENO, DAVID AUSTIN, DAHLKE, JOSHUA RYAN, WITKOS, FAITH ELIZABETH, BLAKE, JAMES FRANCIS, CLARK, WESLEY DEWITT, COWDREY, CONNOR JAMES, KNAPP, ELLEN MARGARET, O'LEARY, JACOB MATTHEW, BOYS, MARK LAURENCE, ALLEN, SHELLEY
• Format: Patent
• Language: English; French
• Published: 06.10.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4- dihydro-2,7-naphthyridine-1,6(2H,7H)-dione. L'invention concerne un composé de formule I ou un sel pharmaceutiquement acceptable de celui-ci, R1, R2, R3 et R4 étant tels que définis dans la description. L'invention concerne en outre des compositions pharmaceutiques comprenant de tels composés et sels, et des méthodes et des utilisations de tels composés, sels et compositions pour le traitement d'une croissance cellulaire anormale, y compris le cancer, chez un sujet en ayant besoin. L'invention concerne en outre des formes solides de 8-((2-fluoro-4-(méthylthio)phényl)amino)-2-(2-hydroxyéthoxy)-7-méthyl-3,4- dihydro-2,7-naphtyridine-1,6(2H,7H)-dione.