METHOD OF TREATING A CONDITION USING A THERAPEUTICALLY EFFECTIVE DOSE OF THE MALT1 INHIBITOR JNJ -67856633 (1 -(1 -OXO-1,2-DIHYDROISOQUINOLIN-5-YL)-5-(TRIFLUOROMETHYL)-N-(2-(TRIFL UOROMETHYL)PYRIDIN-4-YL)-1 H-PY RAZOLE-4-CARBOXAMIDE)

• Main Authors: PHILIPPAR, ULRIKE, GREWAY, ANTHONY T, WILLEMIN, MARIE E, WILDE, THOMAS C
• Format: Patent
• Language: English; French
• Published: 09.09.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a method of treating a disorder or condition that is affected by the inhibition of MALT1 in a subject in need of treatment, comprising administering a therapeutically effective dose of 1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-N-[2-(trifluoromethyl)pyridin-4-yl]-1H-pyrazole-4-carboxamide (Compound A), or a solvate or pharmaceutically acceptable salt form thereof to said subject, wherein said therapeutically effective dose is defined in the specification. L'invention concerne une méthode de traitement d'un trouble ou d'une affection qui est influencée par l'inhibition de MALT1 chez un patient qui a besoin d'un traitement, comprenant l'administration d'une dose thérapeutiquement efficace de 1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluorométhyl)-N-[2-(trifluorométhyl)pyridin-4-yl]-1H-pyrazole-4-carboxamide (composé A) ou d'un solvate ou d'une forme de sel pharmaceutiquement acceptable correspondant audit patient, ladite dose thérapeutiquement efficace étant définie dans la description.