IMIDAZO[1,2-B]PYRIDAZINE BASED TRICYCLIC COMPOUNDS AS INHIBITORS OF HASPIN AND THERAPEUTIC USES THEREOF

The present invention relates to a group of compounds with a tricyclic core based on imidazo[1,2-b]pyridazine of formula (I) which are inhibitors of HASPIN, whose activity is required for the proliferation of certain tumoral cells, so the compounds of the invention are useful for the prevention and/...

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Main Authors ALBARRAN SANTINO, MARIA ISABEL, CEBRIA GOMEZ, ANTONIO, MALUMBRES MARTINEZ, MARCOS, BLANCO APARICIO, CARMEN, GARCIA GARCIA, ANA BELEN, GOMEZ DE LA OLIVA, CRISTINA ANA, PASTOR FERNANDEZ, JOAQUIN, RODRIGUEZ ARISTEGUI, SONSOLES, MARTINEZ GONZALEZ, SONIA
Format Patent
LanguageEnglish
French
Published 29.09.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a group of compounds with a tricyclic core based on imidazo[1,2-b]pyridazine of formula (I) which are inhibitors of HASPIN, whose activity is required for the proliferation of certain tumoral cells, so the compounds of the invention are useful for the prevention and/or treatment of cancer, alone or in combination with chemotherapeutic agents. La présente invention concerne un groupe de composés ayant un noyau tricyclique à base d'imidazo[1,2-b]pyridazine de formule (I) qui sont des inhibiteurs de HASPIN, dont l'activité est requise pour la prolifération de certaines cellules tumorales, de sorte que les composés selon l'invention sont utiles pour la prévention et/ou le traitement du cancer, seuls ou en combinaison avec des agents chimiothérapeutiques.
Bibliography:Application Number: CA20223204603